{"id":15728,"date":"2020-05-27T19:42:06","date_gmt":"2020-05-27T19:42:06","guid":{"rendered":"https:\/\/sbpt.org.br\/portal\/?p=15728"},"modified":"2020-05-27T19:42:06","modified_gmt":"2020-05-27T19:42:06","slug":"resumo-cientifico-covid-14","status":"publish","type":"post","link":"https:\/\/sbpt.org.br\/portal\/resumo-cientifico-covid-14\/","title":{"rendered":"COVID-19: resumos de artigos selecionados &#8211; parte 14"},"content":{"rendered":"<p style=\"text-align: justify\">Veja o artigo sobre tromboembolismo e COVID-19 publicado no Annals of Internal Medicine e o artigo que analisa a possibilidade de predi\u00e7\u00e3o de casos leves e graves de COVID-19 em um hospital da China, publicado no Journal of Clinical Virology.<\/p>\n<p style=\"text-align: justify\"><strong>Autopsy Findings and Venous Thromboembolism in Patients with\u00a0 <\/strong><strong>COVID-19<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>Autores:<\/strong><\/p>\n<p style=\"text-align: justify\">Wichmann D<sup>1<\/sup>, Sperhake J-P<sup>1<\/sup>, L\u00fctgehetmann M<sup>1<\/sup>, Steurer S<sup>1<\/sup>, Edler C<sup>1<\/sup>, Heinemann A<sup>1<\/sup>, Heinrich F<sup>1<\/sup>, Mushumba H<sup>1<\/sup>, Kniep I<sup>1<\/sup>, Schr\u00f6der AS<sup>1<\/sup>, Burdelski C<sup>1<\/sup>, de Heer G<sup>1<\/sup>, Nierhaus A<sup>1<\/sup>, Frings D<sup>1<\/sup>, Pfefferle S<sup>1<\/sup>, Becker H<sup>2<\/sup>, Bredereke-Wiedling H<sup>3<\/sup>, de Weerth A<sup>4<\/sup>, Paschen H-R<sup>5<\/sup>, Sheikhzadeh-Eggers S<sup>6<\/sup>, Stang A<sup>2<\/sup>, Schmiedel S<sup>1<\/sup>, Bokemeyer C<sup>1<\/sup>, Addo MM<sup>1<\/sup>, Aepfelbacher M<sup>1<\/sup>, P\u00fcschel K<sup>1<\/sup>, Kluge S<sup>1<\/sup><\/p>\n<p style=\"text-align: justify\">Proced\u00eancia:<\/p>\n<ol style=\"text-align: justify\">\n<li>Universidade Medical Center Hamburg-Eppendorf, Hamburg, Alemanha;<\/li>\n<li>Hospital Asklepios Barmbek, Hamburgo, Alemanha;<\/li>\n<li>Hospital Bethesda Bergedorf, Hamburgo, Alemanha;<\/li>\n<li>Hospital Agaplesion Diakonie, Hamburgo, Alemanha;<\/li>\n<li>Hospital Amalie Sieveking, Hamburgo, Alemanha;<\/li>\n<li>Hospital Asklepios Saint Georg, Hamburgo, Alemanha<\/li>\n<\/ol>\n<p style=\"text-align: justify\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>Resumo<\/strong><\/p>\n<p style=\"text-align: justify\">Os autores descrevem os achados de aut\u00f3psia completa (inclusive tomografia <em>post-mortem<\/em>, histopatologia e an\u00e1lise virol\u00f3gica) de 12 pacientes com COVID-19 (<em>coronavirus disease 2019<\/em>) em Hamburgo, Alemanha. Todas as aut\u00f3psias foram realizadas no Departamento de Medicina Legal da University Medical Center Hamburg-Eppendorf.<\/p>\n<ul style=\"text-align: justify\">\n<li><u>Caracter\u00edsticas da popula\u00e7\u00e3o estudada<\/u>:<\/li>\n<li>Idade m\u00e9dia de 73 anos.<\/li>\n<li>75%<\/li>\n<li>10 indiv\u00edduos morreram no hospital. Metade destes indiv\u00edduos encontravam-se sob diretrizes avan\u00e7adas de cuidados de suporte quando vieram a \u00f3bito.<\/li>\n<li>50% dos indiv\u00edduos possu\u00edam diagn\u00f3stico cl\u00ednico de doen\u00e7a arterial coronariana, e 25% diagn\u00f3stico de DPOC ou asma.<\/li>\n<li><u>Achados:<\/u><\/li>\n<li>Ocorr\u00eancia de tromboembolia venosa (TEV) em 7 de 12 pacientes, 2 indiv\u00edduos n\u00e3o apresentavam diagn\u00f3stico cl\u00ednico de TEV.<\/li>\n<li>Tromboembolismo pulmonar foi a causa direta da morte de 4 pacientes (25%).<\/li>\n<li>Houve bilateralidade em todos os indiv\u00edduos com trombose venosa profunda.<\/li>\n<li>Onze pacientes possu\u00edram algum grau de cardiopatia detect\u00e1vel, incluindo a ocorr\u00eancia de esclerose da art\u00e9ria coron\u00e1ria em 7 de 12 pacientes.<\/li>\n<li>Os indiv\u00edduos apresentaram uma clara tend\u00eancia \u00e0 obesidade.<\/li>\n<li>Tr\u00eas indiv\u00edduos apresentaram esplenomegalia.<\/li>\n<li>Observou-se Dano Alveolar Difuso em 8 de 12 pacientes, com importante aumento do peso do pulm\u00e3o.<\/li>\n<li>Todos os indiv\u00edduos apresentaram altas concentra\u00e7\u00f5es de RNA viral no pulm\u00e3o.<\/li>\n<li>Foi identificada viremia moderada em 6 pacientes, sendo constatada alta carga viral no f\u00edgado, rins ou cora\u00e7\u00e3o de 5 destes indiv\u00edduos.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">A alta incid\u00eancia de eventos tromboemb\u00f3licos nos pacientes estudados aponta para importante papel da coagulopatia induzida por COVID-19.<\/p>\n<p style=\"text-align: justify\">Refer\u00eancia:<\/p>\n<ol style=\"text-align: justify\">\n<li>WICHMANN, D. et al. Autopsy Findings and Venous Thromboembolism in Patients with COVID-19. Ann Intern Med. 2020 May 6. doi: 10.7326\/M20-2003<\/li>\n<\/ol>\n<p style=\"text-align: justify\"><a href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/M20-2003\" target=\"_blank\" rel=\"noopener noreferrer\">Clique aqui para ler o artigo na \u00edntegra.<\/a><\/p>\n<p style=\"text-align: justify\">\n<p style=\"text-align: justify\"><strong>Prognostic Value of Interleukin-6, C-Reactive Protein, And Procalcitonin in Patients With COVID-19<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>Autores:<\/strong><\/p>\n<p style=\"text-align: justify\">Liu F<sup>1<\/sup>, Li L<sup>1<\/sup>, Xu M<sup>1<\/sup>, Wu J<sup>1<\/sup>, Luo D<sup>1<\/sup>, Zhu Y<sup>1<\/sup>, Li B<sup>1<\/sup>, Song X<sup>1<\/sup>, Zhou X<sup>1<\/sup><\/p>\n<p style=\"text-align: justify\"><strong>Proced\u00eancia:<\/strong><\/p>\n<ol style=\"text-align: justify\">\n<li>Departamento de Anestesiologia, Hospital Geral do Comando do Teatro Central do PLA, Wuhan, China<\/li>\n<\/ol>\n<p style=\"text-align: justify\"><strong>Resumo<\/strong><\/p>\n<p style=\"text-align: justify\">Os autores investigaram a possibilidade de predi\u00e7\u00e3o da ocorr\u00eancia de casos leves e graves de COVID-19 (<em>coronavirus disease 2019)<\/em> a partir da an\u00e1lise dos n\u00edveis s\u00e9ricos de interleucina 6 (IL-6), Prote\u00edna C Reativa (PCR) e Procalcitonina (PCT) em pacientes com COVID-19 admitidos no General Hospital of Central Theater Command of People\u2019s Liberation Army, China.<\/p>\n<ul style=\"text-align: justify\">\n<li><u>Caracter\u00edsticas do estudo e popula\u00e7\u00e3o analisada<\/u>:\n<ul>\n<li>Estudo retrospectivo e observacional envolvendo 140 pacientes com COVID-19.<\/li>\n<li>Amostras de sangue dos pacientes foram colhidas na manh\u00e3 seguinte \u00e0s suas interna\u00e7\u00f5es.<\/li>\n<li>Gravidade dos casos de COVID-19: 107 pacientes leves, e 33 graves.<\/li>\n<li>Maiores m\u00e9dias de idade foram observadas nos pacientes graves.<\/li>\n<\/ul>\n<\/li>\n<li><u>Resultados<\/u>:\n<ul>\n<li>Na admiss\u00e3o, os pacientes apresentavam dosagens s\u00e9ricas elevadas de:<\/li>\n<li>IL-6, 95 pacientes (67,9%)<\/li>\n<li>PCR, 91 pacientes (65,0%)<\/li>\n<li>PCT, 8 pacientes (5,7%)<\/li>\n<li>Pacientes com n\u00edveis de IL-6 &gt; 32,1 pg\/mL, PCR &gt; 41,8 mg\/L e PCT &gt; 0,07 ng\/mL possu\u00edram maior propens\u00e3o para complica\u00e7\u00f5es graves.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify\">Os achados refor\u00e7am a import\u00e2ncia da tempestade citoc\u00ednica nos pacientes portadores de COVID-19. Valida\u00e7\u00e3o do n\u00edvel s\u00e9rico de PCT como fator independente de gravidade apresenta-se pouco consistente na literatura, por\u00e9m IL-6 e PCR apresentam correla\u00e7\u00e3o significativa e podem ser utilizados como fatores independentes preditivos da gravidade da doen\u00e7a.<\/p>\n<p style=\"text-align: justify\">Refer\u00eancia:<\/p>\n<ol style=\"text-align: justify\">\n<li>Liu, F. Et al. Prognostic Value of Interleukin-6, C-Reactive Protein, And Procalcitonin in Patients With COVID-19J Clin Virol. 2020 Apr 14. doi: 10.1016\/j.jcv.2020.104370<\/li>\n<\/ol>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1386653220301128?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Clique aqui para ler o artigo na \u00edntegra.<\/a><\/p>\n<hr \/>\n<p style=\"text-align: center\">Apoio:<\/p>\n<p><a href=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-11208\" src=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB.png\" alt=\"\" width=\"75\" height=\"66\" srcset=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB.png 403w, https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB-300x264.png 300w\" sizes=\"auto, (max-width: 75px) 100vw, 75px\" \/><\/a><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Veja o artigo sobre tromboembolismo e COVID-19 publicado no Annals of Internal Medicine e o artigo que analisa a possibilidade de predi\u00e7\u00e3o de casos leves e graves de COVID-19 em um hospital da China, publicado no Journal of Clinical Virology. Autopsy Findings and Venous Thromboembolism in Patients with\u00a0 COVID-19 Autores: Wichmann D1, Sperhake J-P1, L\u00fctgehetmann [&hellip;]<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":3,"featured_media":15566,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ngg_post_thumbnail":0,"footnotes":""},"categories":[68],"tags":[117,118],"class_list":["post-15728","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-coronavirus","tag-covid-19"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>COVID-19: resumos de artigos selecionados - parte 14 - sbpt.org.br<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sbpt.org.br\/portal\/resumo-cientifico-covid-14\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COVID-19: resumos de artigos selecionados - parte 14 - sbpt.org.br\" \/>\n<meta property=\"og:description\" content=\"Veja o artigo sobre tromboembolismo e COVID-19 publicado no Annals of Internal Medicine e o artigo que analisa a possibilidade de predi\u00e7\u00e3o de casos leves e graves de COVID-19 em um hospital da China, publicado no Journal of Clinical Virology. 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