{"id":15635,"date":"2020-05-22T16:30:59","date_gmt":"2020-05-22T16:30:59","guid":{"rendered":"https:\/\/sbpt.org.br\/portal\/?p=15635"},"modified":"2020-05-22T16:30:59","modified_gmt":"2020-05-22T16:30:59","slug":"resumo-cientifico-covid-13","status":"publish","type":"post","link":"https:\/\/sbpt.org.br\/portal\/resumo-cientifico-covid-13\/","title":{"rendered":"COVID-19: resumos de artigos selecionados &#8211; parte 13"},"content":{"rendered":"<p style=\"text-align: justify\">Leia a resenha de um estudo de coorte publicado no ATS Journal, que analisou as c\u00e9lulas do escarro de 330 pacientes com asma grave, e o artigo de revis\u00e3o da Nature, que tra\u00e7a um paralelo com a fisiopatologia e imunologia de outros coronav\u00edrus direcionados ao trato respirat\u00f3rio inferior.<\/p>\n<p style=\"text-align: justify\"><strong>COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids<\/strong><\/p>\n<p style=\"text-align: justify\"><strong>Resumo<\/strong><\/p>\n<p style=\"text-align: justify\">Os autores do artigo publicado na ATS journal em abril analisaram a express\u00e3o gen\u00e9tica de ECA2 (enzima conversora de angiotensina 2), PRSTMS2 (protease serina transmembrana 2), prote\u00ednas da superf\u00edcie das c\u00e9lulas que se acredita serem alvo do SARS-CoV-2 para infec\u00e7\u00e3o celular.<\/p>\n<p style=\"text-align: justify\">Os pesquisadores analisaram c\u00e9lulas de escarro de 330 pacientes participantes de uma coorte de portadores de asma grave para entender se o aumento da express\u00e3o dessas prote\u00ednas pelas c\u00e9lulas pulmonares aumentaria a susceptibilidade \u00e0 infec\u00e7\u00e3o pelo v\u00edrus, bem como ao desenvolvimento de formas mais graves da doen\u00e7a. Os principais achados foram:<\/p>\n<ul style=\"text-align: justify\">\n<li>A express\u00e3o gen\u00e9tica de ECA2 foi menor que PRSTMS2, e os n\u00edveis de ambos os genes foram semelhantes em asm\u00e1ticos e controles sadios.<\/li>\n<li>Dentre pacientes asm\u00e1ticos, as caracter\u00edsticas que se correlacionaram com uma maior express\u00e3o gen\u00e9tica para ECA2 e PRSTMS2 foram: sexo masculino, ra\u00e7a afroamericana e hist\u00f3ria de diabetes mellitus.<\/li>\n<li>O uso de cortic\u00f3ide inalado (CI) se associou com uma menor express\u00e3o gen\u00e9tica para ECA2 e PRSTMS2.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">Esses achados s\u00e3o importantes na identifica\u00e7\u00e3o de subgrupos de pacientes asm\u00e1ticos com uma maior susceptibilidade \u00e0 infec\u00e7\u00e3o pelo SARS-CoV-2 e fatores de risco possivelmente associados ao desenvolvimento de formas mais graves de COVID-19. S\u00e3o necess\u00e1rios mais estudos para&nbsp; associar um poss\u00edvel efeito protetor do uso de CI em rela\u00e7\u00e3o \u00e0 susceptibilidade e morbidade relaciondas ao novo coronav\u00edrus.<\/p>\n<p style=\"text-align: justify\">Refer\u00eancia:<\/p>\n<ol style=\"text-align: justify\">\n<li>Peters MC. Et al. COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. <em>Am J Respir Crit Care Med<\/em>. 2020 Apr 29. doi: 10.1164\/rccm.202003-0821OC2<\/li>\n<\/ol>\n<p style=\"text-align: justify\"><a href=\"https:\/\/www.atsjournals.org\/doi\/pdf\/10.1164\/rccm.202003-0821OC\" target=\"_blank\" rel=\"noopener noreferrer\">Clique aqui para ler o artigo na \u00edntegra.<\/a><\/p>\n<p style=\"text-align: justify\"><strong><br><\/strong><strong>The Trinity of COVID-19: Immunity, Inflammation and Intervention<\/strong><\/p>\n<p><strong>Resumo<\/strong><\/p>\n<p style=\"text-align: justify\">Neste artigo de revis\u00e3o os autores discutem os diversos mecanismos da infec\u00e7\u00e3o e imunopatog\u00eanese relacionados com a SARS-CoV-2, tra\u00e7ando um paralelo com a fisiopatologia e imunologia de outros coronav\u00edrus direcionados ao trato respirat\u00f3rio inferior humano e destacando a contribui\u00e7\u00e3o das respostas imunes disfuncionais para a progress\u00e3o da doen\u00e7a, onde os principais pontos foram:<\/p>\n<ul style=\"text-align: justify\">\n<li>A infec\u00e7\u00e3o pelo SARS-CoV-2 pode estar associada a rea\u00e7\u00f5es inflamat\u00f3rias agressivas, que resultam em dano \u00e0s vias a\u00e9reas e cuja gravidade se relaciona diretamente \u00e0 resposta imune.<\/li>\n<li>Pode ser detectada atividade de linf\u00f3citos B e T em resposta ao SARS-CoV-2 por volta de uma semana ap\u00f3s o in\u00edcio dos sintomas.<\/li>\n<li>Em alguns pacientes, uma resposta imune disfuncional (de causa mal definida) \u00e9 desencadeada por a\u00e7\u00e3o viral sobre mon\u00f3citos e macr\u00f3fagos, provocando uma produ\u00e7\u00e3o aberrante de citocinas, com importantes danos sist\u00eamicos.<\/li>\n<\/ul>\n<p style=\"text-align: justify\">Ainda existe necessidade de uma investiga\u00e7\u00e3o detalhada dos fatores determinantes de respostas imunes adequadas ou disfuncionais, auxiliando na identifica\u00e7\u00e3o de biomarcadores correlatos de imunidade. O controle da resposta inflamat\u00f3ria, com terapias que regulem aspectos disfuncionais do sistema imune, pode ser t\u00e3o importante quanto o pr\u00f3prio combate direto \u00e0 COVID-19. Terapias com a\u00e7\u00e3o inibit\u00f3ria da replica\u00e7\u00e3o viral poderiam atuar em sinergia com a regula\u00e7\u00e3o do sistema imune disfuncional.<\/p>\n<p style=\"text-align: justify\">Refer\u00eancia:<\/p>\n<ol style=\"text-align: justify\">\n<li>ZIRUI TAY, M. Et al. The Trinity of Covid-19: Immunity, Inflammation And Intervention. Nature Reviews Immunology, 2020.<\/li>\n<\/ol>\n<p style=\"text-align: left\"><a href=\"https:\/\/www.nature.com\/articles\/s41577-020-0311-8.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Clique aqui para ler o artigo na \u00edntegra.<\/a><\/p>\n<p>&nbsp;<\/p>\n<hr>\n<p style=\"text-align: center\">Apoio:<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-11208\" src=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB-300x264.png\" alt=\"\" width=\"75\" height=\"66\" srcset=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB-300x264.png 300w, https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2018\/11\/GSK_LOS_PORTUGUESE_RGB.png 403w\" sizes=\"auto, (max-width: 75px) 100vw, 75px\" \/><\/a><\/p>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Leia a resenha de um estudo de coorte publicado no ATS Journal, que analisou as c\u00e9lulas do escarro de 330 pacientes com asma grave, e o artigo de revis\u00e3o da Nature, que tra\u00e7a um paralelo com a fisiopatologia e imunologia de outros coronav\u00edrus direcionados ao trato respirat\u00f3rio inferior. COVID-19 Related Genes in Sputum Cells in [&hellip;]<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":3,"featured_media":14596,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ngg_post_thumbnail":0,"footnotes":""},"categories":[68],"tags":[117,118],"class_list":["post-15635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-coronavirus","tag-covid-19"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>COVID-19: resumos de artigos selecionados - parte 13 - sbpt.org.br<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sbpt.org.br\/portal\/resumo-cientifico-covid-13\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COVID-19: resumos de artigos selecionados - parte 13 - sbpt.org.br\" \/>\n<meta property=\"og:description\" content=\"Leia a resenha de um estudo de coorte publicado no ATS Journal, que analisou as c\u00e9lulas do escarro de 330 pacientes com asma grave, e o artigo de revis\u00e3o da Nature, que tra\u00e7a um paralelo com a fisiopatologia e imunologia de outros coronav\u00edrus direcionados ao trato respirat\u00f3rio inferior. 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