{"id":12760,"date":"2019-05-21T01:54:08","date_gmt":"2019-05-21T01:54:08","guid":{"rendered":"https:\/\/sbpt.org.br\/portal\/?p=12760"},"modified":"2019-05-21T02:04:52","modified_gmt":"2019-05-21T02:04:52","slug":"cpnpc-nordeste-jbp","status":"publish","type":"post","link":"https:\/\/sbpt.org.br\/portal\/cpnpc-nordeste-jbp\/","title":{"rendered":"Artigo tra\u00e7a o perfil molecular do CPCNP no Nordeste do Brasil"},"content":{"rendered":"<p style=\"text-align: justify;\">Em artigo publicado no <a href=\"http:\/\/www.jornaldepneumologia.com.br\" target=\"_blank\" rel=\"noopener\">Jornal Brasileiro de Pneumologia<\/a>, os autores avaliaram 173 pacientes com adenocarcinoma pulmonar da regi\u00e3o Nordeste do Brasil, com o objetivo de tra\u00e7ar o perfil molecular do c\u00e2ncer de pulm\u00e3o de c\u00e9lulas n\u00e3o pequenas (CPCNP).<\/p>\n<p style=\"text-align: justify;\">&#8220;A realidade do Nordeste \u00e9 diferente do que \u00e9 visto em popula\u00e7\u00f5es de outras regi\u00f5es do pa\u00eds e do mundo. H\u00e1 uma maior incid\u00eancia de rearranjo de gene ALK (10,4%) e de express\u00e3o prot\u00e9ica de PD-L1 (40,5%)&#8221;, constataram os pesquisadores.<\/p>\n<p style=\"text-align: justify;\">Esses biomarcadores s\u00e3o fundamentais no acesso aos medicamentos da terapia-alvo para o CPCNP. As drogas s\u00e3o de alto custo, por\u00e9m, mais espec\u00edficas, mais eficazes e com menos efeitos adversos. Portanto, uma vez identificadas, as express\u00f5es das muta\u00e7\u00f5es gen\u00e9ticas contribuem para personalizar o tratamento do c\u00e2ncer de pulm\u00e3o de c\u00e9lulas n\u00e3o-pequenas.<\/p>\n<p style=\"text-align: justify;\">&#8220;Para efetivar essas terapias alvo, \u00e9 necess\u00e1ria a identifica\u00e7\u00e3o de biomarcadores por linhas metodol\u00f3gicas adequadas, al\u00e9m de estudos populacionais para cria\u00e7\u00e3o de pol\u00edticas de acesso. Mais estudos com informa\u00e7\u00f5es cl\u00ednicas e gen\u00e9ticas s\u00e3o necess\u00e1rios para confirmar essas diferen\u00e7as, al\u00e9m de levantamentos que se concentrem em popula\u00e7\u00f5es em diferentes \u00e1reas do pa\u00eds&#8221;, complementaram os cientistas.<\/p>\n<p><a href=\"http:\/\/www.jornaldepneumologia.com.br\/detalhe_artigo.asp?id=2999\" target=\"_blank\" rel=\"attachment noopener wp-att-12763\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-12763\" src=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-2.png\" alt=\"\" width=\"500\" height=\"288\" srcset=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-2.png 500w, https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-2-300x173.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/www.jornaldepneumologia.com.br\/detalhe_artigo.asp?id=2999\" target=\"_blank\" rel=\"noopener\">Clique para ler o artigo completo no Jornal Brasileiro de Pneumologia.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/sbpt.org.br\/portal\/?attachment_id=12765\" target=\"_blank\" rel=\"attachment noopener wp-att-12764\"><img decoding=\"async\" class=\"aligncenter size-full wp-image-12764\" src=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-3.png\" alt=\"\" width=\"694\" height=\"192\" srcset=\"https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-3.png 694w, https:\/\/d1xe7tfg0uwul9.cloudfront.net\/sbpt-portal\/wp-content\/uploads\/2019\/05\/jbp-3-300x83.png 300w\" sizes=\"(max-width: 694px) 100vw, 694px\" \/><\/a><a href=\"https:\/\/sbpt.org.br\/portal\/cpnpc-nordeste-jbp\/6_provenv_jbp_2019-0139_pt\/\" rel=\"attachment wp-att-12765\">Leia ainda o editorial &#8220;A import\u00e2ncia da caracteriza\u00e7\u00e3o molecular no c\u00e2ncer de pulm\u00e3o&#8221;.<\/a><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Em artigo publicado no Jornal Brasileiro de Pneumologia, os autores avaliaram 173 pacientes com adenocarcinoma pulmonar da regi\u00e3o Nordeste do Brasil, com o objetivo de tra\u00e7ar o perfil molecular do c\u00e2ncer de pulm\u00e3o de c\u00e9lulas n\u00e3o pequenas (CPCNP). &#8220;A realidade do Nordeste \u00e9 diferente do que \u00e9 visto em popula\u00e7\u00f5es&#8230;<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":7,"featured_media":11978,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ngg_post_thumbnail":0,"footnotes":""},"categories":[37],"tags":[254,374,311,310,264,234],"acf":[],"publishpress_future_action":{"enabled":false,"date":"2025-06-25 07:08:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/posts\/12760"}],"collection":[{"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/comments?post=12760"}],"version-history":[{"count":6,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/posts\/12760\/revisions"}],"predecessor-version":[{"id":12768,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/posts\/12760\/revisions\/12768"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/media\/11978"}],"wp:attachment":[{"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/media?parent=12760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/categories?post=12760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sbpt.org.br\/portal\/wp-json\/wp\/v2\/tags?post=12760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}